Review and evaluation of methods correcting for population stratification with a focus on underlying statistical principles.

ABSTRACT: When two or more populations have been separated by geographic or cultural boundaries for many generations, drift, spontaneous mutations, differential selection pressures and other factors may lead to allele frequency differences among populations. If these 'parental' populations subsequently come together and begin inter-mating, disequilibrium among linked markers may span a greater genetic distance than it typically does among populations under panmixia [see glossary]. This extended disequilibrium can make association studies highly effective and more economical than disequilibrium mapping in panmictic populations since less marker loci are needed to detect regions of the genome that harbor phenotype-influencing loci. However, under some circumstances, this process of intermating (as wel

SUBMITTER: Tiwari HK 

PROVIDER: S-EPMC2803696 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature