The effects of baseline characteristics, glycaemia treatment approach, and glycated haemoglobin concentration on the risk of severe hypoglycaemia: post hoc epidemiological analysis of the ACCORD study.

ABSTRACT:

Objectives

To investigate potential determinants of severe hypoglycaemia, including baseline characteristics, in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial and the association of severe hypoglycaemia with levels of glycated haemoglobin (haemoglobin A(1C)) achieved during therapy.

Design

Post hoc epidemiological analysis of a double 2x2 factorial, randomised, controlled trial.

Setting

Diabetes clinics, research clinics, and primary care clinics.

Participants

10 209 of the 10 251 participants enrolled in the ACCORD study with type 2 diabetes, a haemoglobin A(1C) concentration of 7.5% or more during screening, and aged 40-79 years with established cardiovascular disease or 55-79 years with evidence of significant atherosclerosis, albuminu

SUBMITTER: Miller ME 

PROVIDER: S-EPMC2803743 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature