Quantitative comparison of microarray experiments with published leukemia related gene expression signatures.

ABSTRACT:

Background

Multiple gene expression signatures derived from microarray experiments have been published in the field of leukemia research. A comparison of these signatures with results from new experiments is useful for verification as well as for interpretation of the results obtained. Currently, the percentage of overlapping genes is frequently used to compare published gene signatures against a signature derived from a new experiment. However, it has been shown that the percentage of overlapping genes is of limited use for comparing two experiments due to the variability of gene signatures caused by different array platforms or assay-specific influencing parameters. Here, we present a robust approach for a systematic and quantitative comparison of published gene expression signat

SUBMITTER: Klein HU 

PROVIDER: S-EPMC2803858 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature