Co-expression networks: graph properties and topological comparisons.

ABSTRACT:

Motivation

Microarray-based gene expression data have been generated widely to study different biological processes and systems. Gene co-expression networks are often used to extract information about groups of genes that are 'functionally' related or co-regulated. However, the structural properties of such co-expression networks have not been rigorously studied and fully compared with known biological networks. In this article, we aim at investigating the structural properties of co-expression networks inferred for the species Saccharomyces Cerevisiae and comparing them with the topological properties of the known, well-established transcriptional network, MIPS physical network and protein-protein interaction (PPI) network of yeast.

Results

These topological comparisons ind

SUBMITTER: Xulvi-Brunet R 

PROVIDER: S-EPMC2804297 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature