The transcription factor RBP-J is essential for retinal cell differentiation and lamination.

ABSTRACT:

Background

The highly ordered vertebrate retina is composed of seven cell types derived from a common pool of retinal progenitor cells (RPCs), and is a good model for the studies of cell differentiation and interaction during neural development. Notch signaling plays a pivotal role in retinogenesis in mammals, but the full scope of the functions of Notch pathway, and the underlying molecular mechanisms, remain unclear.

Results

In this study, we conditionally knocked out RBP-J, the critical transcription factor downstream to all four Notch receptors, in RPCs of mouse retina at different developmental stages. Disruption of RBP-J at early retinogenesis resulted in accelerated RPCs differentiation, but only photoreceptors and ganglion cells were overrepresented, with other neuro

SUBMITTER: Zheng MH 

PROVIDER: S-EPMC2804697 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature