A rigorous and comprehensive validation: common genetic variations and lung cancer.

ABSTRACT:

Background

Multiple recent genome-wide studies of single nucleotide polymorphisms (SNP) reported associations between candidate chromosome loci and lung cancer susceptibility. We evaluated five of the top candidate SNPs (rs402710, rs2736100, rs4324798, rs16969968, and rs8034191) for their effects on lung cancer risk and overall survival.

Methods

Over 1,700 cases and 2,200 controls were included in this study. Seven independent, complementary case-control data sets were tested for risk assessment encompassing cigarette smokers and never smokers, using unrelated controls and unaffected full-sibling controls. Five patient groups were tested for survival prediction stratified by smoking status, histology subtype, and treatment.

Results

After considering a history of chron

SUBMITTER: Yang P 

PROVIDER: S-EPMC2805461 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature