Association of mitotic regulation pathway polymorphisms with pancreatic cancer risk and outcome.

ABSTRACT:

Background

Mitosis is a highly regulated process that serves to ensure the fidelity of cell division. The disruption of mitotic regulators leading to aneuploidy and polyploidy is commonly observed in cancer cells. Single nucleotide polymorphisms (SNP) in regulators of mitosis may promote chromosome missegregation and influence pancreatic cancer and/or survival.

Methods

Thirty-four SNPs, previously associated with breast cancer risk, from 33 genes involved in the regulation of mitosis, were investigated for associations with pancreatic cancer risk in 1,143 Caucasian patients with pancreatic adenocarcinoma and 1,097 unaffected controls from the Mayo Clinic. Associations with survival from pancreatic cancer were also assessed using 1,030 pancreatic cancer cases with known outco

SUBMITTER: Couch FJ 

PROVIDER: S-EPMC2805468 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature