Multiple genetic variants in telomere pathway genes and breast cancer risk.

ABSTRACT:

Purpose

To explore the etiologic role of genetic variants in telomere pathway genes and breast cancer risk.

Methods

A population-based case-control study, the Long Island Breast Cancer Study Project, was conducted, and 1,067 cases and 1,110 controls were included in the present study. Fifty-two genetic variants of nine telomere-related genes were genotyped.

Results

Seven single nucleotide polymorphisms (SNP) showed significant case-control differences at the level of P < 0.05. The top three statistically significant SNPs under a dominant model were TERT-07 (rs2736109), TERT-54 (rs3816659), and POT1-03 (rs33964002). The odds ratios (OR) were 1.56 [95% confidence interval (95% CI), 1.22-1.99] for the TERT-07 G-allele, 1.27 (95% CI, 1.05-1.52) for the TERT-54 T-allele, a

SUBMITTER: Shen J 

PROVIDER: S-EPMC2805470 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature