Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach.

ABSTRACT:

Context

Associations between adiposity and circulating inflammation markers are assumed to be causal, although the direction of the relationship has not been proven.

Objective

The aim of the study was to explore the causal direction of the relationship between adiposity and inflammation using a bidirectional Mendelian randomization approach.

Methods

In the PROSPER study of 5804 elderly patients, we related C-reactive protein (CRP) single nucleotide polymorphisms (SNPs) (rs1800947 and rs1205) and adiposity SNPs (FTO and MC4R) to body mass index (BMI) as well as circulating levels of CRP and leptin. We gave each individual two allele scores ranging from zero to 4, counting each pair of alleles related to CRP levels or BMI.

Results

With increasing CRP allele score

SUBMITTER: Welsh P 

PROVIDER: S-EPMC2805500 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature