Relaxin gene family in teleosts: phylogeny, syntenic mapping, selective constraint, and expression analysis.

ABSTRACT:

Background

In recent years, the relaxin family of signaling molecules has been shown to play diverse roles in mammalian physiology, but little is known about its diversity or physiology in teleosts, an infraclass of the bony fishes comprising approximately 50% of all extant vertebrates. In this paper, 32 relaxin family sequences were obtained by searching genomic and cDNA databases from eight teleost species; phylogenetic, molecular evolutionary, and syntenic data analyses were conducted to understand the relationship and differential patterns of evolution of relaxin family genes in teleosts compared with mammals. Additionally, real-time quantitative PCR was used to confirm and assess the tissues of expression of five relaxin family genes in Danio rerio and in situ hybridization us

SUBMITTER: Good-Avila SV 

PROVIDER: S-EPMC2805637 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature