Functional diversity of human protein kinase splice variants marks significant expansion of human kinome.

ABSTRACT:

Background

Protein kinases are involved in diverse spectrum of cellular processes. Availability of draft version of the human genomic data in the year 2001 enabled recognition of repertoire of protein kinases. However, over the years the human genomic data is being refined and the current release of human genomic data has helped us to recognize a larger repertoire of over 900 human protein kinases represented mainly by splice variants.

Results

Many of these identified protein kinases are alternatively spliced products. Interestingly, some of the human kinase splice variants appear to be significantly diverged in terms of their functional properties as represented by incorporation or absence of one or more domains. Many sets of protein kinase splice variants have substantiall

SUBMITTER: Anamika K 

PROVIDER: S-EPMC2805699 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature