Genome-wide analyses of gene expression during mouse endochondral ossification.

ABSTRACT:

Background

Endochondral ossification is a complex process involving a series of events that are initiated by the establishment of a chondrogenic template and culminate in its replacement through the coordinated activity of osteoblasts, osteoclasts and endothelial cells. Comprehensive analyses of in vivo gene expression profiles during these processes are essential to obtain a complete understanding of the regulatory mechanisms involved.

Methodology/principal findings

To address these issues, we completed a microarray screen of three zones derived from manually segmented embryonic mouse tibiae. Classification of genes differentially expressed between each respective zone, functional categorization as well as characterization of gene expression patterns, cytogenetic loci, sign

SUBMITTER: James CG 

PROVIDER: S-EPMC2805713 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature