Gene expression factors as predictors of genetic risk and survival in chronic lymphocytic leukemia.

ABSTRACT:

Background

A variety of surrogate markers for genetic features and outcome have been described in chronic lymphocytic leukemia based on gene expression analyses. Previous studies mostly focused on individual markers and selected disease characteristics, which makes it difficult to estimate the relative value of the novel markers. Therefore, in the present study a comprehensive approach was chosen investigating 18 promising, partly novel expression markers in a well characterized cohort of patients with long clinical follow-up and full genetic information (IGHV status, genomic abnormalities).

Design and methods

Expression markers were evaluated using real-time quantitative reverse transcriptase polymerase chain reaction in CD19(+)-purified samples from 151 patients. Multivari

SUBMITTER: Kienle D 

PROVIDER: S-EPMC2805743 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature