Nitric oxide conduction by the brain aquaporin AQP4.

ABSTRACT: Involvement of aquaporins in gas conduction across the membrane and the physiological significance of this process have attracted marked attention from both experimental and theoretical studies. Previous work demonstrated that AQP1 is permeable to both CO(2) and O(2). Here we employ various simulation techniques to examine the permeability of the brain aquaporin AQP4 to NO and O(2) and to describe energetics and pathways associated with these phenomena. The energy barrier to NO and O(2) permeation through AQP4 central pore is found to be only approximately 3 kcal mol(-1). The results suggest that the central pore of AQP4, similar to that of AQP1, can indeed conduct gas molecules. Interestingly, despite a longer and narrower central pore, AQP4 appears to provide an energetically more favora

SUBMITTER: Wang Y 

PROVIDER: S-EPMC2805761 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature