Central oxytocin is involved in restoring impaired gastric motility following chronic repeated stress in mice.

ABSTRACT: Accumulation of continuous life stress (chronic stress) often causes gastric symptoms. The development of gastric symptoms may depend on how humans adapt to the stressful events in their daily lives. Although acute stress delays gastric emptying and alters upper gastrointestinal motility in rodents, the effects of chronic stress on gastric motility and its adaptation mechanism remains unclear. Central oxytocin has been shown to have antistress effects. We studied whether central oxytocin is involved in mediating the adaptation mechanism following chronic repeated stress. Mice were loaded with acute and chronic stress (repeated stress for five consecutive days), and solid gastric emptying and postprandial gastric motility were compared between acute and chronic repeated stress. Expression o

SUBMITTER: Babygirija R 

PROVIDER: S-EPMC2806214 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature