Global transcriptional response after exposure of fission yeast cells to ultraviolet light.

ABSTRACT:

Background

In many cell types, including the fission yeast Schizosaccharomyces pombe, a set of checkpoints are induced by perturbations of the cell cycle or by DNA damage. Many of the checkpoint responses include a substantial change of the transcriptional pattern. As part of characterising a novel G1/S checkpoint in fission yeast we have investigated whether a transcriptional response is induced after irradiation with ultraviolet light.

Results

Microarray analyses were used to measure the global transcription levels of all open reading frames of fission yeast after 254 nm ultraviolet irradiation, which is known to induce a G1/S checkpoint. We discovered a surprisingly weak transcriptional response, which is quite unlike the marked changes detected after some other types of

SUBMITTER: Skjolberg HC 

PROVIDER: S-EPMC2806298 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature