PALB2 variants in hereditary and unselected Finnish prostate cancer cases.

ABSTRACT:

Background

PALB2 1592delT mutation is associated with increased breast cancer and suggestive prostate cancer (PRCA) risk in Finland. In this study we wanted to assess if any other PALB2 variants associate to increased PRCA risk and clinically describe patients with formerly found PALB2 1592delT mutation.

Methods

Finnish families with two or more PRCA cases (n = 178) and unselected cases (n = 285) with complete clinical data were initially screened for variants in the coding region and splice sites of PALB2. Potentially interesting variants were verified in additional set of unselected cases (n = 463).

Results

From our clinically defined sample set we identified total of six variants in PALB2. No novel variants among Finnish PRCA cases were found. Clinical characterist

SUBMITTER: Pakkanen S 

PROVIDER: S-EPMC2806404 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature