A randomized double-blind trial on perioperative administration of probiotics in colorectal cancer patients.

ABSTRACT:

Aim

To investigate whether probiotic bacteria, given perioperatively, might adhere to the colonic mucosa, reduce concentration of pathogens in stools, and modulate the local immune function.

Methods

A randomized, double-blind clinical trial was carried out in 31 subjects undergoing elective colorectal resection for cancer. Patients were allocated to receive either a placebo (group A, n = 10), or a dose of 10(7) of a mixture of Bifidobacterium longum (BB536) and Lactobacillus johnsonii (La1) (group B, n = 11), or the same mixture at a concentration of 10(9) (group C, n = 10). Probiotics, or a placebo, were given orally 2 doses/d for 3 d before operation. The same treatment continued postoperatively from day two to day four. Stools were collected before treatment, during surge

SUBMITTER: Gianotti L 

PROVIDER: S-EPMC2806554 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature