Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn's disease patients.

ABSTRACT:

Aim

To investigate the interaction of interleukin-23 receptor (IL23R) (rs1004819 and rs2201841), autophagy-related 16-like 1 (ATG16L1) (rs2241880), caspase recruitment domain-containing protein 15 (CARD15) genes, and IBD5 locus in Crohn's disease (CD) patients.

Methods

A total of 315 unrelated subjects with CD and 314 healthy controls were genotyped. Interactions and specific genotype combinations of a total of eight variants were tested. The variants of IBD5 locus (IGR2198a_1 rs11739135 and IGR2096a_1 rs12521868), CARD15 (R702W rs2066845 and L1007fs rs2066847), ATG16L1 (rs2241880) and IL23R (rs1004819, rs2201841) genes were genotyped by PCR-RFLP, the G908R (rs2066844) in CARD15 was determined by direct sequencing.

Results

The association of ATG16L1 T300A with CD was

SUBMITTER: Csongei V 

PROVIDER: S-EPMC2806555 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature