Evaluating NAT2PRED for inferring the individual acetylation status from unphased genotype data.

ABSTRACT:

Background

Genetically determined differences in N-acetylation capacity have proved to be important determinants of both the effectiveness of therapeutic response and the development of adverse drug reactions and toxicity during drug treatment. NAT2PRED is a web-server that allows a fast determination of NAT2 acetylation phenotype from genotype data without taking the extra step of reconstructing haplotypes for each individual (publicly available at http://nat2pred.rit.albany.edu). However, the classification accuracy of NAT2PRED needs to be assessed before its application can be advocated at a large scale.

Methods

The ability of NAT2PRED to classify individuals according to their acetylation status (slow, intermediate and rapid acetylators) was evaluated in a worldwide data

SUBMITTER: Sabbagh A 

PROVIDER: S-EPMC2806877 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature