Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health Study.

ABSTRACT:

Background

Low vitamin B-6 status has been linked to an increased risk of cardiovascular diseases. The cardioprotective effects of vitamin B-6 independent of homocysteine suggest that additional mechanisms may be involved.

Objective

Our objective was to examine the cross-sectional association of vitamin B-6 status with markers of inflammation and oxidative stress.

Design

We measured plasma pyridoxal-5'-phosphate (PLP), C-reactive protein (CRP), and an oxidative DNA damage marker, urinary 8-hydroxydeoxyguanosine (8-OHdG), in Puerto Rican adults who were living in Massachusetts (n = 1205, aged 45-75 y).

Results

There was a strong dose-response relation of plasma PLP concentration with plasma CRP. Increasing quartiles of PLP were significantly associated with lowe

SUBMITTER: Shen J 

PROVIDER: S-EPMC2806890 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature