Identification of potential therapeutic targets for Burkholderia cenocepacia by comparative transcriptomics.

ABSTRACT:

Background

Burkholderia cenocepacia is an endemic soil dweller and emerging opportunistic pathogen in patients with cystic fibrosis (CF). The identification of virulence factors and potential therapeutic targets has been hampered by the genomic diversity within the species as many factors are not shared among the pathogenic members of the species.

Methodology/principal findings

In this study, global identification of putative virulence factors was performed by analyzing the transcriptome of two related strains of B. cenocepacia (one clinical, one environmental) under conditions mimicking cystic fibrosis sputum versus soil. Soil is a natural reservoir for this species; hence, genes induced under CF conditions relative to soil may represent adaptations that have occurred in cl

SUBMITTER: Yoder-Himes DR 

PROVIDER: S-EPMC2806911 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature