The Ron receptor tyrosine kinase positively regulates angiogenic chemokine production in prostate cancer cells.

ABSTRACT: Overexpression of the Ron receptor tyrosine kinase has recently been shown in a wide variety of human cancers. However, no studies have examined Ron receptor expression or function during prostate tumorigenesis. In this study we report that Ron is highly expressed in human prostate adenocarcinoma and metastatic lymph nodes when compared with normal prostate or benign prostate hyperplasia. Furthermore, we show that Ron is overexpressed in PC-3 and DU145 prostate cancer cell lines, and that the levels of angiogenic chemokines produced by prostate cancer cells positively correlate with Ron expression. The knockdown of Ron in PC-3 or DU145 cells results in a significant decrease in angiogenic chemokine production and is associated with a decreased activation of the transcription factor nuclear

SUBMITTER: Thobe MN 

PROVIDER: S-EPMC2806938 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature