Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study.

ABSTRACT:

Objectives

To assess the performance of a panel of common single nucleotide polymorphisms (genotypes) associated with type 2 diabetes in distinguishing incident cases of future type 2 diabetes (discrimination), and to examine the effect of adding genetic information to previously validated non-genetic (phenotype based) models developed to estimate the absolute risk of type 2 diabetes.

Design

Workplace based prospective cohort study with three 5 yearly medical screenings.

Participants

5535 initially healthy people (mean age 49 years; 33% women), of whom 302 developed new onset type 2 diabetes over 10 years.

Outcome measures

Non-genetic variables included in two established risk models-the Cambridge type 2 diabetes risk score (age, sex, drug treatment, family his

SUBMITTER: Talmud PJ 

PROVIDER: S-EPMC2806945 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature