Autobiographical memory in semantic dementia: a longitudinal fMRI study.

ABSTRACT: Whilst patients with semantic dementia (SD) are known to suffer from semantic memory and language impairments, there is less agreement about whether memory for personal everyday experiences, autobiographical memory, is compromised. In healthy individuals, functional MRI (fMRI) has helped to delineate a consistent and distributed brain network associated with autobiographical recollection. Here we examined how the progression of SD affected the brain's autobiographical memory network over time. We did this by testing autobiographical memory recall in a SD patient, AM, with fMRI on three occasions, each one year apart, during the course of his disease. At the outset, his autobiographical memory was intact. This was followed by a gradual loss in recollective quality that collapsed only late i

SUBMITTER: Maguire EA 

PROVIDER: S-EPMC2806951 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature