APOE, CETP and LPL genes show strong association with lipid levels in Greek children.

ABSTRACT:

Background and aims

Studies have consistently demonstrated that variants in a number of candidate genes are significant determinants of lipid levels in adults. However, few studies have investigated the impact of these variants in children. Therefore, in the present investigation we examined the influence of ten common variants in the genes for lipoprotein lipase (LPL-S447X), cholesterol ester transfer protein (CETP-Taq1B) apolipoprotein (APO) E (epsilon2, epsilon3, epsilon4), APOA5 (-1131C>T and S19W), APOA4 (S347T) and APOC3 (-482C>T; 1100C>T and 3238G>C) on lipoprotein levels children from the Gene-Diet Attica Investigation on childhood obesity (GENDAI).

Methods and results

The ten variants selected were genotyped in 882 Greek children, mean age: 11.2+/-0.7 years (418 fem

SUBMITTER: Smart MC 

PROVIDER: S-EPMC2807029 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature