The ClC-3 Cl-/H+ antiporter becomes uncoupled at low extracellular pH.

ABSTRACT: Adenovirus expressing ClC-3 (Ad-ClC-3) induces Cl(-)/H(+) antiport current (I(ClC-3)) in HEK293 cells. The outward rectification and time dependence of I(ClC-3) closely resemble an endogenous HEK293 cell acid-activated Cl(-) current (ICl(acid)) seen at extracellular pH

SUBMITTER: Matsuda JJ 

PROVIDER: S-EPMC2807314 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature