Expression analysis of novel striatal-enriched genes in Huntington disease.

ABSTRACT: Selective degeneration of striatal neurons is a pathologic hallmark of Huntington disease (HD). The exact mechanism(s) behind this specific neurodegeneration is still unknown. Expression studies of diseased human post-mortem brain, as well as different mouse models exhibiting striatal degeneration, have demonstrated changes in the expression of many important genes with a large proportion of changes being observed in the striatal-enriched genes. These investigations have raised questions about how enrichment of particular transcripts in the striatum can lead to its selective vulnerability to neurodegeneration. Monitoring the expression changes of striatal-enriched genes during the course of the disease may be informative about their potential involvement in selective degeneration. In this

SUBMITTER: Mazarei G 

PROVIDER: S-EPMC2807369 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature