Changes to the natural killer cell repertoire after therapeutic hepatitis B DNA vaccination.

ABSTRACT:

Background

Improvements to the outcome of adaptive immune responses could be achieved by inducing specific natural killer (NK) cell subsets which can cooperate with dendritic cells to select efficient T cell responses. We previously reported the induction or reactivation of T cell responses in chronic hepatitis B patients vaccinated with a DNA encoding hepatitis B envelope proteins during a phase I clinical trial.

Methodology/principal findings

In this study, we examined changes in the peripheral NK cell populations occurring during this vaccine trial using flow cytometry analysis. Despite a constant number of NK cells in the periphery, a significant increase in the CD56(bright) population was observed after each vaccination and during the follow up. Among the 13 different N

SUBMITTER: Scott-Algara D 

PROVIDER: S-EPMC2807462 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature