Association of a functional microsatellite within intron 1 of the BMP5 gene with susceptibility to osteoarthritis.

ABSTRACT:

Background

In a previous study carried out by our group, the genotyping of 36 microsatellite markers from within a narrow interval of chromosome 6p12.3-q13 generated evidence for linkage and for association to female hip osteoarthritis (OA), with the most compelling association found for a marker within intron 1 of the bone morphogenetic protein 5 gene (BMP5). In this study, we aimed to further categorize the association of variants within intron 1 of BMP5 with OA through an expanded genetic association study of the intron and subsequent functional analysis of associated polymorphisms.

Methods

We genotyped 18 common polymorphisms including 8 microsatellites and 9 single nucleotide polymorphisms (SNPs) and 1 insertion/deletion (INDEL) from within highly conserved regions betw

SUBMITTER: Wilkins JM 

PROVIDER: S-EPMC2807860 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature