Array-based DNA methylation profiling of primary lymphomas of the central nervous system.

ABSTRACT:

Background

Although primary lymphomas of the central nervous system (PCNSL) and extracerebral diffuse large B-cell lymphoma (DLBCL) cannot be distinguished histologically, it is still a matter of debate whether PCNSL differ from systemic DLBCL with respect to their molecular features and pathogenesis. Analysis of the DNA methylation pattern might provide further data distinguishing these entities at a molecular level.

Methods

Using an array-based technology we have assessed the DNA methylation status of 1,505 individual CpG loci in five PCNSL and compared the results to DNA methylation profiles of 49 DLBCL and ten hematopoietic controls.

Results

We identified 194 genes differentially methylated between PCNSL and normal controls. Interestingly, Polycomb target genes an

SUBMITTER: Richter J 

PROVIDER: S-EPMC2807878 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature