Low-concentration ozone reacts with plasmalogen glycerophosphoethanolamine lipids in lung surfactant.

ABSTRACT: Ozone is a common environmental toxicant to which individuals are exposed to on a daily basis. While biochemical end points such as increased mortality, decrements in pulmonary function, and initiation of inflammatory processes are known, little is actually understood regarding the chemical mechanisms underlying changes in pulmonary health, especially for low concentrations of ozone. This study was undertaken to investigate ozone-induced oxidation of endogenous lipids that are potentially exposed to environmental ozone within lung, specifically focusing on plasmalogen glycerophospholipids present in pulmonary surfactant. Sensitive liquid chromatography-mass spectrometry methods were developed to follow oxidation of diacyl and plasmalogen phosphatidylethanolamine (PE) phospholipids and to i

SUBMITTER: Wynalda KM 

PROVIDER: S-EPMC2807911 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature