GSK690693 delays tumor onset and progression in genetically defined mouse models expressing activated Akt.

ABSTRACT:

Purpose

Akt plays a central role in regulating tumor cell survival and cell cycle progression and is regarded as a promising therapeutic target. We used genetically defined mouse models that develop spontaneous tumors exhibiting activated Akt to determine if Akt inhibition by GSK690693 is effective in the treatment of cancer. The broad long-term objective of this project was to use preclinical cancer models with precisely defined genetic lesions to elucidate the efficacy of targeting Akt with GSK690693.

Experimental design

We tested the in vivo effects of GSK690693 in Lck-MyrAkt2 transgenic mice that develop lymphomas, heterozygous Pten(+/-) knockout mice that exhibit endometrial tumors, and TgMISIIR-TAg-DR26 mice that develop ovarian carcinomas, all of which exhibit hyperac

SUBMITTER: Altomare DA 

PROVIDER: S-EPMC2807995 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature