Calcium influx mechanisms underlying calcium oscillations in rat hepatocytes.

ABSTRACT: UNLABELLED:The process of capacitative or store-operated Ca(2+) entry has been extensively investigated, and recently two major molecular players in this process have been described. Stromal interacting molecule (STIM) 1 acts as a sensor for the level of Ca(2+) stored in the endoplasmic reticulum, and Orai proteins constitute pore-forming subunits of the store-operated channels. Store-operated Ca(2+) entry is readily demonstrated with protocols that provide extensive Ca(2+) store depletion; however, the role of store-operated entry with modest and more physiological cell stimuli is less certain. Recent studies have addressed this question in cell lines; however, the role of store-operated entry during physiological activation of primary cells has not been extensively investigated, and ther

SUBMITTER: Jones BF 

PROVIDER: S-EPMC2808042 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature