Genomic profiling of messenger RNAs and microRNAs reveals potential mechanisms of TWEAK-induced skeletal muscle wasting in mice.

ABSTRACT:

Background

Skeletal muscle wasting is a devastating complication of several physiological and pathophysiological conditions. Inflammatory cytokines play an important role in the loss of skeletal muscle mass in various chronic diseases. We have recently reported that proinflammatory cytokine TWEAK is a major muscle-wasting cytokine. Emerging evidence suggests that gene expression is regulated not only at transcriptional level but also at post-transcriptional level through the expression of specific non-coding microRNAs (miRs) which can affect the stability and/or translation of target mRNA. However, the role of miRs in skeletal muscle wasting is unknown.

Methodology/principal findings

To understand the mechanism of action of TWEAK in skeletal muscle, we performed mRNA and miR

SUBMITTER: Panguluri SK 

PROVIDER: S-EPMC2808241 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature