The role of emerging and investigational therapies for metastatic brain tumors: a systematic review and evidence-based clinical practice guideline of selected topics.

ABSTRACT:

Question

What evidence is available regarding the emerging and investigational therapies for the treatment of metastatic brain tumors?

Target population

These recommendations apply to adults with brain metastases.

Recommendations

New radiation sensitizers Level 2 A subgroup analysis of a large prospective randomized controlled trial (RCT) suggested a prolongation of time to neurological progression with the early use of motexafin-gadolinium (MGd). Nonetheless this was not borne out in the overall study population and therefore an unequivocal recommendation to use the currently available radiation sensitizers, motexafin-gadolinium and efaproxiral (RSR 13) cannot be provided. Interstitial modalities There is no evidence to support the routine use of new or existing inte

SUBMITTER: Olson JJ 

PROVIDER: S-EPMC2808529 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature