Males with familial idiopathic scoliosis: a distinct phenotypic subgroup.

ABSTRACT:

Study design

Statistical analysis of genomic screening and fine mapping data.

Objective

The goals of this study were to analyze a region on chromosome 17 and to identify specific genetic determinants within this region linked to familial idiopathic scoliosis (FIS) in a subgroup of families in which affected males have undergone surgery.

Summary of background data

The high prevalence and variability of FIS is indicative of genetic heterogeneity. To localize genes related to scoliosis, identification of groups of families with common clinical characteristics is a strategy that reduces genetic heterogeneity. Two independent studies have implicated a region on chromosome 17 as related to FIS.

Methods

With approval of the Institutional Review Board, the initial stud

SUBMITTER: Clough M 

PROVIDER: S-EPMC2808704 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature