Postmenopausal estrogen and progestin effects on the serum proteome.

ABSTRACT:

Background

Women's Health Initiative randomized trials of postmenopausal hormone therapy reported intervention effects on several clinical outcomes, with some important differences between estrogen alone and estrogen plus progestin. The biologic mechanisms underlying these effects, and these differences, have yet to be fully elucidated.

Methods

Baseline serum samples were compared with samples drawn 1 year later for 50 women assigned to active hormone therapy in both the estrogen-plus-progestin and estrogen-alone randomized trials, by applying an in-depth proteomic discovery platform to serum pools from 10 women per pool.

Results

In total, 378 proteins were quantified in two or more of the 10 pooled serum comparisons, by using strict identification criteria. Of these,

SUBMITTER: Pitteri SJ 

PROVIDER: S-EPMC2808737 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature