PepX: a structural database of non-redundant protein-peptide complexes.

ABSTRACT: Although protein-peptide interactions are estimated to constitute up to 40% of all protein interactions, relatively little information is available for the structural details of these interactions. Peptide-mediated interactions are a prime target for drug design because they are predominantly present in signaling and regulatory networks. A reliable data set of nonredundant protein-peptide complexes is indispensable as a basis for modeling and design, but current data sets for protein-peptide interactions are often biased towards specific types of interactions or are limited to interactions with small ligands. In PepX (http://pepx.switchlab.org), we have designed an unbiased and exhaustive data set of all protein-peptide complexes available in the Protein Data Bank with peptide lengths up t

SUBMITTER: Vanhee P 

PROVIDER: S-EPMC2808939 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature