ComSin: database of protein structures in bound (complex) and unbound (single) states in relation to their intrinsic disorder.

ABSTRACT: Most of the proteins in a cell assemble into complexes to carry out their function. In this work, we have created a new database (named ComSin) of protein structures in bound (complex) and unbound (single) states to provide a researcher with exhaustive information on structures of the same or homologous proteins in bound and unbound states. From the complete Protein Data Bank (PDB), we selected 24 910 pairs of protein structures in bound and unbound states, and identified regions of intrinsic disorder. For 2448 pairs, the proteins in bound and unbound states are identical, while 7129 pairs have sequence identity 90% or larger. The developed server enables one to search for proteins in bound and unbound states with several options including sequence similarity between the corresponding prot

SUBMITTER: Lobanov MY 

PROVIDER: S-EPMC2808974 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature