In vivo amyloid imaging in autopsy-confirmed Parkinson disease with dementia.

ABSTRACT:

Objective

To investigate the specificity of in vivo amyloid imaging with [(11)C]-Pittsburgh Compound B (PIB) in Parkinson disease dementia (PDD).

Methods

We performed detailed neuropathologic examination for 3 individuals with PDD who had PIB PET imaging within 15 months of death.

Results

We observed elevated cortical uptake of [(11)C]-PIB on in vivo PET imaging in 2 of the 3 cases. At autopsy, all 3 individuals had abundant cortical Lewy bodies (Braak PD stage 6), and were classified as low-probability Alzheimer disease (AD) based on NIA-Reagan criteria. The 2 PIB-positive individuals had abundant diffuse Abeta plaques but only sparse neuritic plaques and intermediate neurofibrillary tangle pathology. The PIB-negative individual had rare diffuse plaques, no neuritic

SUBMITTER: Burack MA 

PROVIDER: S-EPMC2809026 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature