Genome wide association for addiction: replicated results and comparisons of two analytic approaches.

ABSTRACT:

Background

Vulnerabilities to dependence on addictive substances are substantially heritable complex disorders whose underlying genetic architecture is likely to be polygenic, with modest contributions from variants in many individual genes. "Nontemplate" genome wide association (GWA) approaches can identity groups of chromosomal regions and genes that, taken together, are much more likely to contain allelic variants that alter vulnerability to substance dependence than expected by chance.

Methodology/principal findings

We report pooled "nontemplate" genome-wide association studies of two independent samples of substance dependent vs control research volunteers (n = 1620), one European-American and the other African-American using 1 million SNP (single nucleotide polymorphis

SUBMITTER: Drgon T 

PROVIDER: S-EPMC2809089 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature