MicroRNA-145 targets YES and STAT1 in colon cancer cells.

ABSTRACT:

Background

MicroRNAs (miRNAs) have emerged as important gene regulators and are recognized as key players in tumorigenesis. miR-145 is reported to be down-regulated in several cancers, but knowledge of its targets in colon cancer remains limited.

Methodology/principal findings

To investigate the role of miR-145 in colon cancer, we have employed a microarray based approach to identify miR-145 targets. Based on seed site enrichment analyses and unbiased word analyses, we found a significant enrichment of miRNA binding sites in the 3'-untranslated regions (UTRs) of transcripts down-regulated upon miRNA overexpression. Gene Ontology analysis showed an overrepresentation of genes involved in cell death, cellular growth and proliferation, cell cycle, gene expression and cancer. A

SUBMITTER: Gregersen LH 

PROVIDER: S-EPMC2809101 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature