Intrauterine exposure to maternal diabetes is associated with higher adiposity and insulin resistance and clustering of cardiovascular risk markers in Indian children.

ABSTRACT:

Objective

To test the hypothesis that maternal gestational diabetes increases cardiovascular risk markers in Indian children.

Research design and methods

Anthropometry, blood pressure, and glucose/insulin concentrations were measured in 514 children at 5 and 9.5 years of age (35 offspring of diabetic mothers [ODMs], 39 offspring of diabetic fathers [ODFs]). Children of nondiabetic parents were control subjects.

Results

At age 9.5 years, female ODMs had larger skinfolds (P < 0.001), higher glucose (30 min) and insulin concentrations, and higher homeostasis model assessment (HOMA) of insulin resistance and systolic blood pressure (P < 0.05) than control subjects. Male ODMs had higher HOMA (P < 0.01). Associations were stronger than at age 5 years. Female ODFs had larger

SUBMITTER: Krishnaveni GV 

PROVIDER: S-EPMC2809291 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature