Histone deacetylases play a major role in the transcriptional regulation of the Plasmodium falciparum life cycle.

ABSTRACT: The apparent paucity of molecular factors of transcriptional control in the genomes of Plasmodium parasites raises many questions about the mechanisms of life cycle regulation in these malaria parasites. Epigenetic regulation has been suggested to play a major role in the stage specific gene expression during the Plasmodium life cycle. To address some of these questions, we analyzed global transcriptional responses of Plasmodium falciparum to a potent inhibitor of histone deacetylase activities (HDAC). The inhibitor apicidin induced profound transcriptional changes in multiple stages of the P. falciparum intraerythrocytic developmental cycle (IDC) that were characterized by rapid activation and repression of a large percentage of the genome. A major component of this response was induction

SUBMITTER: Chaal BK 

PROVIDER: S-EPMC2809759 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature