Immune-based therapeutics for pediatric cancer.

ABSTRACT:

Importance of the field

Although most children with cancer are cured, there remain significant limitations of standard treatment, most notably chemotherapy resistance and non-specific toxicities. Novel immune-based therapies that target pediatric malignancies offer attractive adjuncts and/or alternatives to commonly employed cytotoxic regimens of chemotherapy or radiotherapy. Elucidation of the principles of tumor biology and the development of novel laboratory technologies over the last decade have led to substantial progress in bringing immunotherapies to the bedside.

Areas covered in this review

Current immunotherapeutic clinical trials in pediatric oncology and the science behind their development are reviewed.

What the reader will gain

Most of the immune-based th

SUBMITTER: Capitini CM 

PROVIDER: S-EPMC2809805 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature