Changes in peroxisome proliferator-activated receptor-gamma activity in children with septic shock.

ABSTRACT:

Purpose

To assess changes in peroxisome proliferator-activated receptor-gamma (PPARgamma) in peripheral blood mononuclear cells (PBMC) from critically ill children with sepsis. Additionally, to investigate the effects of sepsis on the endogenous activator of PPARgamma, 15-deoxy-(12,14)-PGJ(2) (15d-PGJ(2)), and the downstream targets of PPARgamma activity, adiponectin and resistin.

Methods

Single-center, prospective case-control study in critically ill children with systemic inflammatory response syndrome, sepsis or septic shock.

Results

PPARgamma nuclear protein expression was decreased but PPARgamma activity was increased in PBMC from children with septic shock compared with controls. PPARgamma activity on day 1 was significantly higher in patients with higher pediat

SUBMITTER: Kaplan JM 

PROVIDER: S-EPMC2809814 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature