TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action.

ABSTRACT:

Objective

Common variants in the gene TCF7L2 confer the largest effect on the risk of type 2 diabetes. The present study was undertaken to increase our understanding of the mechanisms by which this gene affects type 2 diabetes risk.

Research design and methods

Eight subjects with risk-conferring TCF7L2 genotypes (TT or TC at rs7903146) and 10 matched subjects with wild-type genotype (CC) underwent 5-h oral glucose tolerance test (OGTT), isoglycemic intravenous glucose infusion, and graded glucose infusion (GGI). Mathematical modeling was used to quantify insulin-secretory profiles during OGTT and glucose infusion protocols. The incretin effect was assessed from ratios of the insulin secretory rates (ISR) during oral and isoglycemic glucose infusions. Dose-response curves rel

SUBMITTER: Villareal DT 

PROVIDER: S-EPMC2809956 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature