Prokineticin 2 is a hypothalamic neuropeptide that potently inhibits food intake.

ABSTRACT:

Objective

Prokineticin 2 (PK2) is a hypothalamic neuropeptide expressed in central nervous system areas known to be involved in food intake. We therefore hypothesized that PK2 plays a role in energy homeostasis.

Research design and methods

We investigated the effect of nutritional status on hypothalamic PK2 expression and effects of PK2 on the regulation of food intake by intracerebroventricular (ICV) injection of PK2 and anti-PK2 antibody. Subsequently, we investigated the potential mechanism of action by determining sites of neuronal activation after ICV injection of PK2, the hypothalamic site of action of PK2, and interaction between PK2 and other hypothalamic neuropeptides regulating energy homeostasis. To investigate PK2's potential as a therapeutic target, we investiga

SUBMITTER: Gardiner JV 

PROVIDER: S-EPMC2809973 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature