Role of Scrib and Dlg in anterior-posterior patterning of the follicular epithelium during Drosophila oogenesis.

ABSTRACT:

Background

Proper patterning of the follicle cell epithelium over the egg chamber is essential for the Drosophila egg development. Differentiation of the epithelium into several distinct cell types along the anterior-posterior axis requires coordinated activities of multiple signaling pathways. Previously, we reported that lethal(2)giant larvae (lgl), a Drosophila tumor suppressor gene, is required in the follicle cells for the posterior follicle cell (PFC) fate induction at mid-oogenesis. Here we explore the role of another two tumor suppressor genes, scribble (scrib) and discs large (dlg), in the epithelial patterning.

Results

We found that removal of scrib or dlg function from the follicle cells at posterior terminal of the egg chamber causes a complete loss of the PFC fa

SUBMITTER: Li Q 

PROVIDER: S-EPMC2810132 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature